Even though his classmates from first grade on have considered him strange and a loser, Daniel Zinkoff's optimism and exuberance and the support of his loving family do not allow him to feel that way about himself.

Living with her warden father in an apartment above a 1950s prison, Cammie O'Reilly struggles to come to terms with the loss of her mother, who died saving her from harm when she was a baby, and interacts with some of the reformed inmates.

Will Tuppence's life has always been ruled by science and common sense but in ninth grade, shaken up by the discovery that protons decay, he begins to see the entire world differently and gains new perspective on his relationships with his little sister and two closest friends.